Trimethoprim-sulfamethoxazole (TMP-SMX), also known as co-trimoxazole, is a combination of two antimicrobial agents that act synergistically against a wide variety of bacteria. Although other combinations of sulfonamides are available with trimethoprim, TMP-SMX is by far the most widely used. This topic will review basic issues related to the Late (tertiary and neurosyphilis)—2,400,000 units at 7-day intervals for three doses. Congenital—under 2 years of age: 50,000 units/kg/body weight; ages 2 to 12 years: adjust dosage based on adult dosage schedule. Yaws, Bejel, and Pinta —1,200,000 units (1 injection). Prophylaxis —for rheumatic fever and glomerulonephritis.

Urinary Tract Infections. Pyelonephritis: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 14 days. Acute Bacterial Rhinosinusitis (Off-label) Severe infection requiring hospitalization. 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5-7 days. Endocarditis (Off-label)

single dose: Skin and skin structure: 800 mg: 400 mg Q 12 hours: 7 to 14 days: Acute maxillary sinusitis: 400 mg: 200 mg Q 12 hours: 10 days: Uncomplicated urinary tract infection: 200 mg: 100 mg Q 12 hours: 7 days CrCl 11-25: Same dose q8h CrCl 0-10: Same dose q12h CrCl 0-10: 200 mg q12h CrCl 25-50: Same dose q12h CrCl 10-24: Same dose q24h CrCl What Is Bactrim? Bactrim (sulfamethoxazole and trimethoprim) I.V. is a combination of two antibiotics used to treat urinary tract infections, acute otitis media, bronchitis, Shigellosis, Pneumocystis pneumonia, traveler's diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), and other bacterial infections susceptible to this antibiotic. Usual Adult Dose for Urinary Tract Infection. 1 to 2 g IV or IM once a day (or in equally divided doses twice a day) Duration of therapy: 4 to 14 days. Complicated infections: Longer therapy may be required. Infections due to Streptococcus pyogenes: At least 10 days; Comments: Dose and duration depend on the nature and severity of the infection. Usual Adult Dose for Tertiary Syphilis. 500 mg orally every 6 hours for 28 days Tetracycline should be used only if penicillins are contraindicated. Usual Adult Dose for Nongonococcal Urethritis. 500 mg orally every 6 hours for 7 days The patient's sexual partner(s) should also be evaluated/treated. Usual Adult Dose for Gonococcal Infection Recommendations for treatment of children with a history of type I hypersensitivity to penicillin vary. 1, 2. In children who are vomiting or who cannot tolerate oral medication, a single dose of ceftriaxone can be used and then can be switched to oral antibiotics if improving. 1. For further recommendations on alternative antibiotic regimens Dosage; Side effects; Interactions; FAQ; What is cephalexin? Cephalexin is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Cephalexin is used to treat infections caused by bacteria, including upper respiratory infections, ear infections, skin infections, urinary tract infections and bone infections.
Brady PW, Conway PH, Goudie A. Length of intravenous antibiotic therapy and treatment failure in infants with urinary tract infections. Pediatrics. 2010 Aug;126(2):196-203. Hewitt IK, Pennesi M, Morello W, et al. Antibiotic Prophylaxis for Urinary Tract Infection-Related Renal Scarring: A Systematic Review. Pediatrics. 2017 May;139(5).
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